Quantitative Imaging Lab

Die Schwerpunkte der Arbeitsgruppe sind:

• Entwicklung neuer Bildgebungsverfahren zur Quantifizierung von Organfibrose und entzündlichen Veränderungen,
• Etablierung quantitativer Messverfahren zur Analyse der Körperzusammensetzung,
• Implementierung von Methoden der Künstlichen Intelligenz (KI) zur Automatisierung von Quantifizierungsverfahren und zur verbesserten Detektion und präziseren Charakterisierung von Organveränderungen.

Das Ziel der Arbeitsgruppe ist die Translation moderner Bildgebungs-, Bildverarbeitungs- und automatisierter Erkennungsverfahren in die klinische Routine, um

• das diagnostische Spektrum bildgebender Verfahren zu erweitern und damit beispielsweise die Anzahl notwendiger invasiver Probeentnahmen (Biopsien) zur Diagnosesicherung zu verringern,
• frühzeitig das Therapieansprechen bzw. den Therapierfolg erfassen zu können,
• durch verbesserte Prognoseabschätzungen therapeutische Ansätze zu individualisieren (personalisierte Medizin).

Deep Learning Super-Resolution Reconstruction for Fast and Motion-Robust T2-weighted Prostate MRI.
Bischoff LM, Peeters JM, Weinhold L, Krausewitz P, Ellinger J, Katemann C, Isaak A, Weber OM, Kuetting D, Attenberger U, Pieper CC, Sprinkart AM, Luetkens JA. 
Radiology. 2023 Sep;308(3):e230427. doi: 10.1148/radiol.230427.

Cardiovascular Magnetic Resonance in Survivors of Critical Illness: Cardiac Abnormalities Are Associated With Acute Kidney Injury.
Isaak A, Pomareda I, Mesropyan N, Kravchenko D, Endler C, Bischoff L, Pieper CC, Kuetting D, Attenberger U, Zimmer S, Putensen C, Schewe JC, Kreyer S, Luetkens JA.
J Am Heart Assoc. 2023 May 2;12(9):e029492. doi: 10.1161/JAHA.123.029492.

Fetal Cardiac Cine MRI with Doppler US Gating in Complex Congenital Heart Disease.
Vollbrecht TM, Hart C, Zhang S, Katemann C, Isaak A, Pieper CC, Kuetting D, Faridi B, Strizek B, Attenberger U, Kipfmueller F, Herberg U, Geipel A, Luetkens JA.
Radiol Cardiothorac Imaging. 2023 Feb 23;5(1):e220129. doi: 10.1148/ryct.220129.

A novel and simple cardiac magnetic resonance score (PE²RT) predicts outcome in takotsubo syndrome.
Isaak A, Bratz J, Kravchenko D, Mesropyan N, Eckardt I, Bischoff LM, Weinhold L, Kuetting D, Pieper CC, Attenberger U, Zimmer S, Luetkens JA.
Eur Radiol. 2023 Aug;33(8):5498-5508. doi: 10.1007/s00330-023-09543-x.

Cardiac involvement in non-cirrhotic portal hypertension: MRI detects myocardial fibrosis and oedema similar to compensated cirrhosis.
Isaak A, Chang J, Mesropyan N, Kravchenko D, Endler C, Bischoff L, Böhling N, Pieper CC, Kuetting D, Strassburg CP, Attenberger U, Jansen C, Praktiknjo M, Luetkens JA.
European Heart Journal - Cardiovascular Imaging. 2022 Nov 24:jeac235. doi: 10.1093/ehjci/jeac235.

T2 Turbo Spin Echo With Compressed Sensing and Propeller Acquisition (Sampling k-Space by Utilizing Rotating Blades) for Fast and Motion Robust Prostate MRI: Comparison With Conventional Acquisition.
Bischoff LM, Katemann C, Isaak A, Mesropyan N, Wichtmann B, Kravchenko D, Endler C, Kuetting D, Pieper CC, Ellinger J, Weber O, Attenberger U, Luetkens JA.
Investigative Radiology. 2022 Sep 1. doi: 10.1097/RLI.0000000000000923.

Layer-specific Strain Analysis with Cardiac MRI Feature Tracking in Acute Myocarditis.
Isaak A, Kravchenko D, Mesropyan N, Endler C, Bischoff LM, Vollbrecht T, Thomas D, Dabir D, Zimmer S, Attenberger U, Kuetting D, Luetkens JA.
Radiology: Cardiothoracic Imaging. 2022 Jun 9;4(3):e210318. doi: 10.1148/ryct.210318.

Cardiac MRI Depicts Immune Checkpoint Inhibitor-induced Myocarditis: A Prospective Study.
Faron A, Isaak A, Mesropyan N, Reinert M, Schwab K, Sirokay J, Sprinkart AM, Bauernfeind FG, Dabir D, Pieper CC, Heine A, Kuetting D, Attenberger U, Landsberg J, Luetkens JA.
Radiology. 2021 Sep 28:210814. doi: 10.1148/radiol.2021210814.

Diagnostic Benefit of MRI for Exclusion of Ligamentous Injury in Patients with Lateral Atlantodental Interval Asymmetry at Initial Trauma CT.
Endler CH, Ginzburg D, Isaak A, Faron A, Mesropyan N, Kuetting D, Pieper CC, Kupczyk PA, Attenberger UI, Luetkens JA.
Radiology. 2021 Sep;300(3):633-640. doi: 10.1148/radiol.2021204187

Cardiac MRI in Patients with Prolonged Cardiorespiratory Symptoms after Mild to Moderate COVID-19 Infection.
Kravchenko D, Isaak A, Zimmer S, Mesropyan N, Reinert M, Faron A, Pieper CC, Heine A, Velten M, Nattermann J, Kuetting D, Duerr GD, Attenberger UI, Luetkens JA.
Radiology. 2021 Aug 10:211162. doi: 10.1148/radiol.2021211162.

Cardiac MRI in Suspected Acute COVID-19 Myocarditis.
Luetkens JA, Isaak A, Öztürk C, Mesropyan N, Monin M, Schlabe S, Reinert M, Faron A, Heine A, Velten M, Dabir D, Boesecke C, Strassburg CP, Attenberger U, Zimmer S, Duerr GD, Nattermann J.
Radiology: Cardiothoracic Imaging. 2021 Mar 4;3(2):e200628. doi: 10.1148/ryct.2021200628.

Free-breathing non-contrast flow-independent cardiovascular magnetic resonance angiography using cardiac gated, magnetization-prepared 3D Dixon method: assessment of thoracic vasculature in congenital heart disease.
Isaak A, Luetkens JA, Faron A, Endler C, Mesropyan N, Katemann C, Zhang S, Kupczyk P, Kuetting D, Attenberger U, Dabir D.
Journal of Cardiovascular Magnetic Resonance. 2021 Jul 19;23(1):91. doi: 10.1186/s12968-021-00788-3.

Diffuse Myocardial Inflammation in COVID-19 Associated Myocarditis Detected by Multiparametric Cardiac Magnetic Resonance Imaging.
Luetkens JA, Isaak A, Zimmer S, Nattermann J, Sprinkart AM, Boesecke C, Rieke GJ, Zachoval C, Heine A, Velten M, Duerr GD.
Circulation: Cardiovascular Imaging. 2020 May;13(5):e010897. doi: 10.1161/CIRCIMAGING.120.010897.

Myocardial Fibrosis and Inflammation in Liver Cirrhosis: MRI Study of the Liver-Heart Axis.
Isaak A, Praktiknjo M, Jansen C, Faron A, Sprinkart AM, Pieper CC, Chang J, Fimmers R, Meyer C, Dabir D, Thomas D, Trebicka J, Attenberger U, Kuetting D, Luetkens JA.
Radiology. 2020 Oct;297(1):51-61. doi: 10.1148/radiol.2020201057. 

Opportunistic Computed Tomography Imaging for the Assessment of Fatty Muscle Fraction Predicts Outcome in Patients Undergoing Transcatheter Aortic Valve Replacement.
Luetkens JA, Faron A, Geissler HL, Al-Kassou B, Shamekhi J, Stundl A, Sprinkart AM, Meyer C, Fimmers R, Treede H, Grube E, Nickenig G, Sinning JM, Thomas D.
Circulation. 2020 Jan 21;141(3):234-236. doi: 10.1161/CIRCULATIONAHA.119.042927. 

Comprehensive Cardiac Magnetic Resonance for Assessment of Cardiac Involvement in Myotonic Muscular Dystrophy Type 1 and 2 Without Known Cardiovascular Disease.
Luetkens JA, von Landenberg C, Isaak A, Faron A, Kuetting D, Gliem C, Dabir D, Kornblum C, Thomas D.
Circulation: Cardiovascular Imaging. 2019 Jun;12(6):e009100. doi: 10.1161/CIRCIMAGING.119.009100.

Quantification of Liver Fibrosis at T1 and T2 Mapping with Extracellular Volume Fraction MRI: Preclinical Results.
Luetkens JA, Klein S, Träber F, Schmeel FC, Sprinkart AM, Kuetting DLR, Block W, Uschner FE, Schierwagen R, Hittatiya K, Kristiansen G, Gieseke J, Schild HH, Trebicka J, Kukuk GM.
Radiology. 2018 Sep;288(3):748-754. doi: 10.1148/radiol.2018180051. 

Incremental value of quantitative CMR including parametric mapping for the diagnosis of acute myocarditis.
Luetkens JA, Homsi R, Sprinkart AM, Doerner J, Dabir D, Kuetting DL, Block W, Andrié R, Stehning C, Fimmers R, Gieseke J, Thomas DK, Schild HH, Naehle CP.
European Heart Journal - Cardiovascular Imaging. 2016 Feb;17(2):154-61. doi: 10.1093/ehjci/jev246. 

Awards

PD Dr. Alexander Isaak, Radiological Society of North America (RSNA) Trainee Research Award 2022

PD Dr. Anton Faron, Radiological Society of North America (RSNA) Trainee Research Award 2020

PD Dr. Alexander Isaak, Young Investigator Award der Deutschen Röntgengesellschaft (DRG) 2020

Ausgezeichnete Publikationen

Myocarditis Following COVID-19 Vaccination, A. Isaak, A. Feisst, J. Luetkens: 2022 Top Images in Radiology

Myocardial Fibrosis and Inflammation in Liver Cirrhosis: MRI Study of the Liver-Heart Axis, A. Isaak et al.: Cardiovascular CT and MRI in 2020: Review of Key Articles